Description

(5Alpha)-4,5-Epoxy-3,14-Dihydroxy-17-(2-Propynyl)Morphinan-6-One is a high-purity, semi-synthetic opioid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of specialized analgesics and is valued for its defined stereochemistry and structural complexity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing next-generation therapeutic agents and conducting structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent opioid analgesics and antagonist compounds for clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore modifications of the morphinan scaffold for new drug discovery.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating opioid receptor binding, signaling pathways, and pharmacological profiles.
• Process Development: Used by fine chemical manufacturers to develop and scale up synthetic routes for complex active pharmaceutical ingredients (APIs).
• Academic Research: A valuable compound for university laboratories studying organic synthesis, pharmacology, and neurochemistry.

Basic Information

Product Name	(5Alpha)-4,5-Epoxy-3,14-Dihydroxy-17-(2-Propynyl)Morphinan-6-One
CAS No.	73232-47-0
Molecular Formula	C20H23NO4
Molecular Weight	341.40 g/mol
Synonyms	17-(2-Propynyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one; 6-Oxomorphinan derivative; 17-Propargyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one; 14-Hydroxy-17-(prop-2-yn-1-yl)-4,5-epoxymorphinan-3,6-diol; Noroxymorphone propargyl derivative; (5α)-4,5-Epoxy-3,14-dihydroxy-17-(prop-2-yn-1-yl)morphinan-6-one
EINECS	Contact for details

Quality Control

Our (5Alpha)-4,5-Epoxy-3,14-Dihydroxy-17-(2-Propynyl)Morphinan-6-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.