Description

4-Chloro-2-Fluorobenzenethiol is a versatile and high-value organosulfur building block, essential for introducing the thiol functional group into complex molecular architectures. Its unique structure, featuring both chlorine and fluorine substituents, makes it a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, where the thiol and halogen groups contribute to biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the creation of novel polymers, liquid crystals, and organic electronic materials due to its reactive thiol moiety.
• Chemical Derivatization: Utilized for the functionalization of surfaces, nanoparticles, and other substrates through thiol-based coupling reactions.

Basic Information

Product Name	4-Chloro-2-Fluorobenzenethiol
CAS No.	73129-12-1
Molecular Formula	C6H4ClFS
Molecular Weight	162.61 g/mol
Synonyms	2-Fluoro-4-chlorobenzenethiol; 4-Chloro-2-fluorothiophenol; 2-Fluoro-4-chlorothiophenol; 1-Chloro-3-fluoro-4-mercaptobenzene; Benzenethiol, 4-chloro-2-fluoro-; (4-Chloro-2-fluorophenyl)thiol; 73129-12-1
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for 4-Chloro-2-Fluorobenzenethiol to ensure batch-to-batch consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by GC or HPLC), suitable for most research and industrial synthesis applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and custom synthesis with higher purity grades (≥98%, ≥99%) is available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress and oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.