Description

Dl-4-Hydroxyphenyl-2,6-D2-Alanine-2-D1 is a deuterium-labeled isotopologue of the amino acid tyrosine, specifically designed for research and analytical applications. This compound is critical for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex biological matrices. It is primarily utilized by pharmaceutical researchers, analytical chemists, and life science laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and stable isotope labeling experiments.

Application

• Internal Standard for LC-MS/MS: Essential for accurate quantification of tyrosine and related metabolites in bioanalytical methods, improving data reliability.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Proteomics & Metabolic Pathway Analysis: Facilitates the study of protein turnover, metabolic fluxes, and cellular signaling pathways using stable isotope labeling techniques.
• Biochemical Research: Serves as a labeled precursor in enzymatic studies and the synthesis of deuterated peptides or complex molecules.
• Quality Control & Method Development: Employed in analytical laboratories for validating assays, ensuring method robustness, and meeting regulatory compliance (e.g., FDA, EMA).

Basic Information

Product Name	Dl-4-Hydroxyphenyl-2,6-D2-Alanine-2-D1
CAS No.	73036-42-7
Molecular Formula	C9H9D3NO3
Molecular Weight	184.21 g/mol (for deuterated form)
Synonyms	DL-Tyrosine-2,6-d2-2-d1; Deuterated DL-Tyrosine; (RS)-2-Amino-3-(4-hydroxyphenyl-2,6-d2)propionic-2-d1 acid; DL-4-Hydroxyphenylalanine-d3; DL-Tyr-d3; Tyrosine (phenyl-2,6-d2, 2-d1); 3-(4-Hydroxyphenyl-2,6-d2)-DL-alanine-2-d1
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management to ensure high isotopic purity and chemical integrity, essential for sensitive analytical applications. Each batch is characterized by advanced techniques including NMR and Mass Spectrometry to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for assay, isotopic enrichment, and impurity profiles. We support research requiring compliance with GMP/GLP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.