Description

L-Tyrosine (3,3-D2) is a stable isotope-labeled analog of the essential amino acid L-Tyrosine, specifically deuterated at the 3,3 positions. This precise labeling is critical for applications requiring high sensitivity and minimal background interference, such as mass spectrometry and metabolic research. It is an indispensable tool for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require reliable internal standards and tracers for quantitative analysis and metabolic pathway studies.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis of amino acids and related metabolites in biological samples.
• Metabolic Pathway Tracing: Employed in deuterium-labeling studies to investigate tyrosine metabolism, protein synthesis rates, and neurotransmitter (dopamine, norepinephrine) biosynthesis.
• Pharmaceutical Research & Development: Serves as a key component in the development and validation of bioanalytical methods for drug candidates targeting neurological and metabolic disorders.
• Nutritional Science Studies: Utilized in clinical and preclinical research to study amino acid absorption, distribution, and utilization using stable isotope techniques.
• Biochemical Reagent: Acts as a specialized substrate or precursor in enzymatic assays and in vitro studies of tyrosine kinase activity and related signaling pathways.
• Isotope Dilution Analysis: Provides high accuracy and precision in the quantification of endogenous L-tyrosine levels in complex matrices like plasma, urine, and tissue homogenates.

Basic Information

Product Name	L-Tyrosine (3,3-D2)
CAS No.	72963-27-0
Molecular Formula	C9H9D2NO3
Molecular Weight	183.20 g/mol
Synonyms	(2S)-2-Amino-3-(4-hydroxyphenyl)propanoic-3,3-d2 acid; L-Tyrosine-d2 (3,3); Tyrosine-3,3-d2; (S)-Tyrosine-3,3-d2; 4-Hydroxy-DL-phenylalanine-3,3-d2; 3-(4-Hydroxyphenyl)-D-alanine-3,3-d2; β-(p-Hydroxyphenyl)alanine-3,3-d2; p-Tyrosine-3,3-d2
EINECS	Contact for details

Quality Control

Our L-Tyrosine (3,3-D2) is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (atom % D), and chiral purity. We adhere to relevant industry standards for fine chemicals and can provide material suitable for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.