Description

Bicyclo[2.2.2]Octane-1-Carboxylic Acid, 4-Hydroxy-, Ethyl Ester is a high-purity, functionalized bicyclic compound serving as a critical chiral building block and synthetic intermediate. Its unique, rigid bicyclo[2.2.2]octane scaffold with hydroxyl and ester functionalities makes it valuable for constructing complex molecular architectures with precise stereochemistry. This compound is essential for researchers and manufacturers in advanced pharmaceutical development, agrochemical synthesis, and materials science, where it is used to impart specific conformational and steric properties to target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing central nervous system (CNS) drugs and other therapeutics requiring rigid, three-dimensional frameworks.
• Agrochemical Research: Used in creating novel pesticides and herbicides, where the bicyclic structure can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Advanced Material Science: Incorporated into specialty polymers and liquid crystals to modify thermal stability, optical properties, and mechanical strength.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, including novel cycloaddition and functionalization reactions.
• Fine Chemical Synthesis: Employed in the multi-step production of complex fragrances, flavors, and other high-value specialty chemicals.

Basic Information

Product Name	Bicyclo[2.2.2]Octane-1-Carboxylic Acid, 4-Hydroxy-, Ethyl Ester
CAS No.	72948-78-8
Molecular Formula	C11H16O3
Molecular Weight	196.24 g/mol
Synonyms	4-Hydroxybicyclo[2.2.2]octane-1-carboxylic acid ethyl ester; Ethyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate; 1-Ethoxycarbonyl-4-hydroxybicyclo[2.2.2]octane; Bicyclo[2.2.2]octan-1-ol, 4-hydroxy-, ethyl ester; 4-Hydroxy-BCO ethyl ester; BCO-HE ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.2]Octane-1-Carboxylic Acid, 4-Hydroxy-, Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical and chiral purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request. We support compliance with cGMP, ISO, and other relevant quality standards for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.