Description

3-(Difluoromethoxy)Benzyl Bromide is a versatile and high-value organobromine building block, essential for introducing the difluoromethoxy-substituted benzyl moiety into complex molecular architectures. Its primary commercial value lies in enabling the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the difluoromethoxy group can significantly enhance metabolic stability and bioavailability. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: Functions as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form biaryl structures.
• Nucleophilic Substitution: The reactive benzyl bromide group allows for efficient alkylation of amines, thiols, and stabilized carbanions.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	3-(Difluoromethoxy)Benzyl Bromide
CAS No.	72768-95-7
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	α-Bromo-3-(difluoromethoxy)toluene; (3-(Difluoromethoxy)phenyl)methyl Bromide; 1-(Bromomethyl)-3-(difluoromethoxy)benzene; 3-(Difluoromethoxy)benzyl Bromide; Benzene, 1-(bromomethyl)-3-(difluoromethoxy)-; 3-Difluoromethoxybenzyl Bromide
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade material, ensuring traceability and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids, bases, and oxidizing agents. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.