Description

tert-Butyldimethylsilyl Iodide is a highly reactive organosilicon reagent primarily used as a versatile protecting agent for alcohols and other functional groups in complex organic synthesis. Its value lies in its ability to introduce the robust tert-butyldimethylsilyl (TBDMS) protecting group under mild conditions, which is crucial for multi-step synthetic sequences. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for the development of active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the protection of hydroxyl groups in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Natural Product and Peptide Chemistry: Used to selectively protect sensitive alcohol functionalities during the synthesis of complex natural products and peptides.
• Agrochemical Manufacturing: Employed in the production of advanced pesticide and herbicide intermediates where selective protection/deprotection strategies are required.
• Material Science Research: Serves as a precursor or modifying agent in the development of novel silicon-containing polymers and advanced organic materials.
• Process Chemistry & Scale-up: A critical tool for process development chemists optimizing large-scale synthetic routes for commercial production.
• Academic & R&D Laboratories: Fundamental reagent for methodological development in organic synthesis and new reaction discovery.

Basic Information

Product Name	tert-Butyldimethylsilyl Iodide
CAS No.	72726-45-5
Molecular Formula	C6H15ISi
Molecular Weight	242.18 g/mol
Synonyms	TBDMS Iodide; Iodotert-butyldimethylsilane; tert-Butyl(dimethyl)iodosilane; (tert-Butyldimethylsilyl)iodide; Iodotrimethylsilane, tert-butyl-; TBDMSI; DTBSI; Silane, iodo(1,1-dimethylethyl)dimethyl-
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilyl Iodide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards expected in pharmaceutical R&D and fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC or Titration)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.