Description

4,4,5,5-Tetramethyl-2-Trimethylsiloxy-[1,3,2]-Dioxaphospholane is a specialized organophosphorus compound featuring a protected phosphite moiety. This compound is a critical reagent in synthetic organic chemistry, particularly valued for its role as a phosphitylating agent in the synthesis of nucleoside phosphoramidites. It is essential for researchers and manufacturers in the oligonucleotide and pharmaceutical industries who require high-purity intermediates for the production of DNA/RNA sequences, antisense oligonucleotides, and other therapeutic nucleic acids.

Application

• Phosphoramidite Synthesis: A key precursor in the automated solid-phase synthesis of oligonucleotides for research, diagnostics, and therapeutics.
• Nucleoside Protection: Used to introduce the phosphite triester group onto nucleosides, a fundamental step in creating building blocks for DNA/RNA synthesis.
• Antisense Oligonucleotide (ASO) Production: Enables the manufacture of ASOs used in gene silencing and targeted therapeutic applications.
• siRNA and miRNA Synthesis: Critical for the production of small interfering RNA and microRNA molecules for genetic research and drug development.
• Pharmaceutical Intermediates: Serves as a building block in the synthesis of complex molecules with potential pharmaceutical activity.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies involving phosphorus chemistry.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-Trimethylsiloxy-[1,3,2]-Dioxaphospholane
CAS No.	72666-09-2
Molecular Formula	C9H21O3PSi
Molecular Weight	236.32 g/mol
Synonyms	2-(Trimethylsiloxy)-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; 2-Trimethylsiloxy-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; NSC 334358; Phosphorodichloridic acid, P-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl] ester; Tetramethyl-2-trimethylsiloxy-[1,3,2]-dioxaphospholane
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-Trimethylsiloxy-[1,3,2]-Dioxaphospholane is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, which is critical for sensitive oligonucleotide synthesis. Each lot undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to confirm identity, purity, and the absence of critical impurities like water or reactive chlorides. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, this product should be handled under an inert atmosphere (argon or nitrogen) and stored with appropriate desiccants. Recommended long-term storage temperature is 2-8°C. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.