Description

α-(Aminomethyl)-5-Methoxy-1H-Indole-3-Acetic Acid Methyl Ester Hydrochloride CAS NO 72318-55-9 is a high-purity indole derivative, specifically a functionalized tryptamine analog, that serves as a critical advanced intermediate in organic synthesis. Its value lies in providing a versatile, protected scaffold for constructing complex molecules with precise stereochemistry and functional group compatibility. This compound is essential for pharmaceutical R&D chemists and process development scientists working on novel central nervous system (CNS) agents, serotonin receptor modulators, and other bioactive indole-based compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel tryptamine-based therapeutics and investigational drugs.
• Neurological Research: Used in the development of compounds targeting serotonin (5-HT) receptors and related neurological pathways.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology: Employed in the synthesis of molecular probes for studying enzyme function and biological mechanisms.

Basic Information

Product Name	α-(Aminomethyl)-5-Methoxy-1H-Indole-3-Acetic Acid Methyl Ester Hydrochloride
CAS No.	72318-55-9
Molecular Formula	C14H19ClN2O3
Molecular Weight	298.77 g/mol
Synonyms	5-Methoxy-α-(aminomethyl)-1H-indole-3-acetic acid methyl ester hydrochloride; Methyl 2-(aminomethyl)-2-(5-methoxy-1H-indol-3-yl)acetate hydrochloride; 5-MeO-AMT methyl ester HCl; 5-Methoxy-α-methyltryptamine methyl ester hydrochloride (precursor); 5-Methoxy-AMT methyl ester hydrochloride; Methyl (5-methoxy-1H-indol-3-yl)-2-(aminomethyl)acetate hydrochloride; 72318-55-9; α-(Aminomethyl)-5-methoxyindole-3-acetic acid methyl ester HCl
EINECS	Contact for details

Quality Control

Our α-(Aminomethyl)-5-Methoxy-1H-Indole-3-Acetic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.