Description

1-Bromo-1-Methoxycyclopropane is a versatile and highly reactive cyclopropane derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and methoxy substituents on the strained three-membered ring, makes it an invaluable precursor for constructing complex molecular frameworks. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to introduce cyclopropane motifs and functionalized side chains into target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing cyclopropane rings, which are common in drug candidates for metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the production of novel pesticides and herbicides, where the cyclopropane unit can enhance biological activity and stability.
• Material Science Precursor: Employed in the development of specialty polymers and advanced organic materials with tailored electronic or mechanical properties.
• Cross-Coupling Reactions: Serves as an electrophilic partner in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.
• Ligand and Catalyst Development: A valuable starting material for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic and R&D Laboratories: Fundamental reagent for methodological studies and exploring new reaction pathways involving strained ring systems.

Basic Information

Product Name	1-Bromo-1-Methoxycyclopropane
CAS No.	72282-90-7
Molecular Formula	C4H7BrO
Molecular Weight	151.00 g/mol
Synonyms	1-Bromo-1-methoxycyclopropane; Methoxycyclopropyl bromide; (1-Bromocyclopropyl)methyl ether; Cyclopropane, 1-bromo-1-methoxy-; 1-Methoxy-1-bromocyclopropane
EINECS	Contact for details

Quality Control

Our 1-Bromo-1-Methoxycyclopropane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and HPLC analysis, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.45 g/cm³
Boiling Point	~135-140 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.