Description

1H-Benzimidazole-5-Carboxylic Acid, 7-(Aminosulfonyl)-1-(2-(4-Chloroph Enyl)Ethyl)- CAS NO 72020-21-4 is a high-purity, advanced pharmaceutical intermediate characterized by its complex benzimidazole core functionalized with sulfonamide and carboxylic acid groups. This compound matters for its critical role in the synthesis of targeted therapeutic agents, particularly in the development of novel enzyme inhibitors and receptor modulators. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the discovery and production of new chemical entities for oncology, metabolic disorders, and cardiovascular diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzimidazole-based active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymes like serine proteases, relevant for antiviral and anti-inflammatory drug candidates.
• Kinase Inhibitor Development: Serves as a core scaffold for creating potent and selective kinase inhibitors for oncology research.
• Chemical Biology & Probe Synthesis: Utilized to create molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for preclinical and clinical trials.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	1H-Benzimidazole-5-Carboxylic Acid, 7-(Aminosulfonyl)-1-(2-(4-Chloroph Enyl)Ethyl)-
CAS No.	72020-21-4
Molecular Formula	C16H14ClN3O4S
Molecular Weight	379.82 g/mol
Synonyms	7-Sulfamoyl-1-[2-(4-chlorophenyl)ethyl]-1H-benzimidazole-5-carboxylic acid; 1-(2-(4-Chlorophenyl)ethyl)-7-sulfamoyl-1H-benzimidazole-5-carboxylic acid; 72020-21-4; Benzimidazole-5-carboxylic acid, 7-(aminosulfonyl)-1-[2-(4-chlorophenyl)ethyl]-; 1H-Benzimidazole-5-carboxylic acid, 7-(aminosulfonyl)-1-[2-(4-chlorophenyl)ethyl]-; 1-(4-Chlorophenethyl)-7-sulfamoyl-1H-benzo[d]imidazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole-5-Carboxylic Acid, 7-(Aminosulfonyl)-1-(2-(4-Chloroph Enyl)Ethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities to ensure compliance with ICH guidelines and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.