Description

D-1,2,3,4-Tetrahydronorharmane-3-Carboxylic Acid is a high-purity, synthetically derived tetrahydro-β-carboline derivative. This compound serves as a critical chiral building block and advanced intermediate in the synthesis of complex pharmaceutical molecules and bioactive alkaloids. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate this privileged scaffold into new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of central nervous system (CNS) active drugs, potential neuroprotective agents, and other therapeutic compounds.
• Medicinal Chemistry Research: Used as a scaffold for constructing compound libraries in drug discovery programs targeting serotonin receptors and related pathways.
• Alkaloid Synthesis: Serves as a sophisticated intermediate for the total synthesis of complex natural products containing the tetrahydro-β-carboline core.
• Biochemical Research: Employed as a reference standard or probe in studies of enzyme inhibition and biochemical mechanism elucidation.
• Fine Chemical Synthesis: Utilized in the preparation of specialized ligands, catalysts, and other high-value chemical entities.

Basic Information

Product Name	D-1,2,3,4-Tetrahydronorharmane-3-Carboxylic Acid
CAS No.	72002-54-1
Molecular Formula	C₁₂H₁₂N₂O₂
Molecular Weight	216.24 g/mol
Synonyms	(1R,3S)-1,2,3,4-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid; (R,S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic Acid; D-Tetrahydro-β-carboline-3-carboxylic Acid; D-THCA; D-THβC-3-COOH; D-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic Acid; (3S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our D-1,2,3,4-Tetrahydronorharmane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing purity, chiral excess, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.