Description

4-Androstene-3,17-Dione-19-D3 is a deuterated analog of the key steroid intermediate androstenedione, where three hydrogen atoms are replaced by deuterium at the 19-methyl position. This isotopic labeling is critical for creating internal standards used in high-precision analytical methods, ensuring accurate quantification and reliable research outcomes. It is an essential material for pharmaceutical R&D, clinical research laboratories, and manufacturers of diagnostic assays and reference materials.

Application

• Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the precise quantification of androstenedione and related steroid hormones in complex biological matrices.
• Pharmaceutical Metabolism and Pharmacokinetic (PK/ADME) Studies: Used as a tracer to investigate the metabolic pathways, bioavailability, and clearance rates of steroid-based pharmaceuticals.
• Clinical Diagnostics and Endocrine Testing: Enables the development and validation of highly accurate clinical assays for measuring androstenedione levels, aiding in the diagnosis of endocrine disorders.
• Biochemical Research: A vital tool for studying steroidogenesis, enzyme kinetics (e.g., aromatase activity), and hormone regulation mechanisms in research settings.
• Reference Standard Production: Used by certified reference material (CRM) producers to create calibrated standards for quality control in analytical laboratories.
• Doping Control Analysis: Employed in sports anti-doping laboratories as a critical component for the definitive identification and quantification of prohibited endogenous steroids.

Basic Information

Product Name	4-Androstene-3,17-Dione-19-D3
CAS No.	71995-66-9
Molecular Formula	C19H23D3O2
Molecular Weight	289.43 g/mol
Synonyms	Androst-4-ene-3,17-dione-19-d3; 19,19,19-Trideuteroandrost-4-ene-3,17-dione; Androstenedione-19-d3; 4-Androstenedione-19-d3; 3,17-Diketo-androst-4-ene-19-d3; AED-19-d3; 19-Trideuteromethyl-androst-4-ene-3,17-dione
EINECS	Contact for details

Quality Control

Every batch of 4-Androstene-3,17-Dione-19-D3 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure high chemical purity and isotopic enrichment, which are paramount for its use as an internal standard. Certificates of Analysis (COA) detailing specifications for assay (by HPLC), isotopic purity (by MS), and identification (by IR and NMR) are supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.