Description

L-4-Hydroxyphenyl-2,6-D2-Alanine-2-D1 is a deuterium-labeled derivative of the amino acid L-tyrosine, a critical isotopically labeled building block for advanced research and development. This compound is essential for creating internal standards in mass spectrometry, enabling highly accurate quantification and metabolic pathway tracing in complex biological matrices. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and the development of novel diagnostic agents.

Application

• Mass Spectrometry Internal Standards: Serves as a critical, isotopically pure reference standard for the precise quantification of L-tyrosine and related metabolites in LC-MS/MS and GC-MS analyses.
• Drug Metabolism Studies (DMPK): Used as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of tyrosine-based pharmaceuticals and biologics.
• Proteomics and Metabolic Pathway Analysis: Enables the study of protein turnover, amino acid flux, and metabolic disorders in cellular and in vivo research models.
• Synthesis of Labeled Compounds: Acts as a key chiral precursor for the synthesis of more complex deuterium-labeled peptides, hormones, and neurotransmitters.
• Clinical Diagnostics Development: Employed in the development and calibration of advanced diagnostic assays for conditions related to tyrosine metabolism.

Basic Information

Product Name	L-4-Hydroxyphenyl-2,6-D2-Alanine-2-D1
CAS No.	71939-39-4
Molecular Formula	C9H7D3NO3
Molecular Weight	184.20 g/mol (for labeled form)
Synonyms	L-Tyrosine-2,6-d2-2-d1; (2S)-2-Amino-3-(4-hydroxyphenyl-2,6-d2)propanoic-2-d1 acid; Deuterated L-Tyrosine; L-Tyrosine-d3; L-Tyrosine (phenyl-2,6-d2, 2-d1); 3-(4-Hydroxyphenyl-2,6-d2)-L-alanine-2-d1; [2,6-D2, 2-D1]-L-Tyrosine
EINECS	Contact for details

Quality Control

Our deuterated amino acids are produced under strict quality systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic methods, including NMR and Mass Spectrometry, to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., D3 ≥ 98%), chemical purity (by HPLC), and specific analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light). For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	D3 ≥ 98 atom % D
Optical Rotation	[α]D20: Specific range provided on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.