Description

3-(5-Chloro-Thiophen-2-Yl)-3-Oxo-Propionitrile is a versatile and high-value organic intermediate characterized by its unique thiophene and cyanoacetate functional groups. This compound is critical for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research and development. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing thiophene or pyridine heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Material Science Research: Serves as a precursor for the development of organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to its electron-withdrawing properties.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where the thiophene moiety contributes to color and stability.
• Ligand and Catalyst Development: Useful for creating novel ligands in coordination chemistry and catalysis research.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	3-(5-Chloro-Thiophen-2-Yl)-3-Oxo-Propionitrile
CAS No.	71683-01-7
Molecular Formula	C7H4ClNOS
Molecular Weight	185.63 g/mol
Synonyms	5-Chloro-2-thienyl cyanomethyl ketone; 3-Oxo-3-(5-chloro-2-thienyl)propanenitrile; 2-Acetyl-5-chlorothiophene-3-carbonitrile; (5-Chloro-2-thienyl)(cyano)methyl ketone; 3-(5-Chloro-2-thienyl)-3-oxopropanenitrile; 5-Chloro-2-cyanomethyl ketone thiophene; β-Oxo-5-chloro-2-thiophenepropionitrile
EINECS	Contact for details

Quality Control

Our 3-(5-Chloro-Thiophen-2-Yl)-3-Oxo-Propionitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.