Description

1,1-Bis(Trimethylsilyl)-3-(o-Chlorophenyl)-2-Thiourea is a specialized organosilicon-protected thiourea derivative, serving as a versatile building block and reagent in advanced organic synthesis. Its core value lies in its dual functionality, offering both a protected thiourea moiety and silyl groups that can be leveraged for further chemical transformations. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex heterocycles and as a precursor in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those containing thiourea or guanidine pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the o-chlorophenyl group is a common bioactive motif.
• Organocatalyst Precursor: Serves as a precursor for generating novel thiourea-based organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of functionalized polymers and advanced materials with specific silyl-group properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme inhibition.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	1,1-Bis(Trimethylsilyl)-3-(o-Chlorophenyl)-2-Thiourea
CAS No.	71457-01-7
Molecular Formula	C13H23ClN2SSi2
Molecular Weight	330.02 g/mol
Synonyms	N,N-Bis(trimethylsilyl)-N'-(2-chlorophenyl)thiourea; 1,1-Bis(trimethylsilyl)-3-(2-chlorophenyl)thiourea; o-Chlorophenyl-1,1-bis(trimethylsilyl)thiourea; 2-Chlorophenyl-1,1-bis(trimethylsilyl)thiourea; BTS-Thiourea derivative; Silylated Thiourea Reagent; Protected Thiourea Reagent
EINECS	Contact for details

Quality Control

Our 1,1-Bis(Trimethylsilyl)-3-(o-Chlorophenyl)-2-Thiourea is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture ingress and decomposition. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.