Description

4-Hydroxy-3-Methoxy-D3-Phenylethylene Glycol 4-Sulphate Potassium Salt is a high-purity, deuterium-labeled derivative of a key catecholamine metabolite, specifically designed for advanced analytical and research applications. This compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and reducing matrix effects in complex biological samples. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers for method development and validation in neurochemical and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous MHPG sulfate in plasma, serum, and cerebrospinal fluid for neurological and psychiatric research.
• Biomarker Assay Development: Used in the development and validation of high-sensitivity diagnostic assays for monitoring catecholamine metabolism and related disorders.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug effects on noradrenergic pathways in preclinical and clinical trials.
• Metabolomics Research: Serves as a stable isotope-labeled reference compound in targeted metabolomic profiling studies of the central nervous system.
• Quality Control in Diagnostics: Employed as a calibrant or control material in the manufacturing of in-vitro diagnostic (IVD) kits for clinical chemistry.
• Forensic Toxicology: Supports analytical methods for the detection and quantification of specific metabolites in forensic investigations.

Basic Information

Product Name	4-Hydroxy-3-Methoxy-D3-Phenylethylene Glycol 4-Sulphate Potassium Salt
CAS No.	71324-20-4
Molecular Formula	C9H6D3KO7S
Molecular Weight	315.32 g/mol (Contact for details)
Synonyms	MHPG-d3 Sulfate Potassium Salt; 3-Methoxy-4-hydroxyphenylglycol-d3 Sulfate Potassium Salt; 4-Hydroxy-3-methoxyphenylglycol-d3 Sulfate K+ Salt; Deuterated MHPG Sulfate Potassium Salt; D3-MHPG Sulfate; (3,4-Dihydroxyphenyl)ethylene glycol-d3 4-sulfate potassium salt; 4-Sulfate Potassium Salt of 4-Hydroxy-3-methoxy-D3-phenylethylene glycol
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-Methoxy-D3-Phenylethylene Glycol 4-Sulphate Potassium Salt is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic purity, and related substances by HPLC and MS. We adhere to cGMP principles for research chemicals, and our quality protocols are designed to meet the exacting standards of pharmaceutical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥95.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.