Description

Bicifadine is a synthetic organic compound of significant interest in pharmaceutical research and development. Its primary value lies in its pharmacological profile as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), making it a key intermediate for investigating novel therapeutic agents. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on central nervous system (CNS) disorders, analgesic development, and neuropharmacology.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological pathways.
• Neuroscience Research: Used in preclinical studies to investigate the mechanisms of triple monoamine reuptake inhibition and its effects on pain modulation and mood disorders.
• Analgesic Drug Development: A key compound for R&D programs aimed at creating new non-opioid or multimodal pain management therapies.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development, validation, and impurity profiling.
• Biochemical Assays: Utilized in in vitro assays to study transporter binding affinity and inhibition kinetics at serotonin, norepinephrine, and dopamine transporters.
• Academic Research: Supports university and institutional research into the structure-activity relationships (SAR) of SNDRI compounds.

Basic Information

Product Name	Bicifadine
CAS No.	71195-57-8
Molecular Formula	C17H19NO
Molecular Weight	253.34 g/mol
Synonyms	(±)-1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane; DOV-21,947; DOV 21947; LW-1-79; (1R,5S)-rel-1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane; Bicifadine Hydrochloride (salt form precursor); SNDRI Bicifadine
EINECS	Contact for details

Quality Control

Our Bicifadine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.