Description

(R)-(-)-Mephenytoin CAS NO 71140-51-7 is the (R)-enantiomer of the anticonvulsant drug mephenytoin, a high-purity chiral building block of significant interest in pharmaceutical research and development. This stereochemically defined compound is crucial for studying stereoselective metabolism, pharmacological activity, and for the synthesis of targeted active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in neuroscience, drug metabolism studies, and the development of enantiomerically pure therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug testing laboratories.
• Metabolic and Pharmacokinetic Studies: Essential for investigating the stereoselective metabolism of mephenytoin, particularly via the CYP2C19 enzyme pathway, which is a key pharmacogenetic marker.
• Chiral Synthetic Intermediate: Serves as a premium starting material or intermediate in the asymmetric synthesis of more complex, biologically active molecules.
• Neuroscience Research: Employed in preclinical research to study the mechanism of action, efficacy, and toxicity profiles of anticonvulsant agents at a molecular level.
• Academic Research & Development: Used in university and institutional labs for chemical education and advanced research in medicinal chemistry and pharmacology.

Basic Information

Product Name	(R)-(-)-Mephenytoin
CAS No.	71140-51-7
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	(R)-5-Ethyl-3-methyl-5-phenylhydantoin; (R)-Mephenytoin; (R)-(-)-3-Methyl-5-phenyl-5-ethylhydantoin; (R)-Nirvanol Precursor; (R)-Enantiomer of Mephenytoin; (5R)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione; (R)-(-)-5-Phenyl-5-ethyl-3-methylhydantoin
EINECS	Contact for details

Quality Control

Our (R)-(-)-Mephenytoin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing lot-specific data on identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.