Description

(S)-Mephenytoin is the S-enantiomer of the anticonvulsant drug mephenytoin, a compound of significant interest in pharmacological research and development. Its primary value lies in its stereoselective activity, making it a crucial reference standard and intermediate for studying drug metabolism, chiral pharmacology, and neurological pathways. This high-purity chiral building block is essential for pharmaceutical R&D laboratories, academic institutions, and manufacturers focused on developing or analyzing enantiomerically pure neuroactive compounds and metabolites.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Research: Critical for studying the stereoselective metabolism of mephenytoin, particularly CYP2C19 enzyme activity, in pharmacokinetic and pharmacogenetic investigations.
• Chiral Intermediate: Serves as a key starting material or intermediate in the synthetic pathways for novel enantiomerically pure therapeutic agents.
• Neurological Research: Employed in preclinical studies to investigate structure-activity relationships (SAR) and the mechanisms of anticonvulsant and neuroactive compounds.
• Analytical Chemistry: Utilized in chromatography (HPLC, GC) as a resolution marker and for calibrating chiral separation systems.
• Biochemical Assays: Applied in vitro assays to probe enzyme inhibition, receptor binding, and other biochemical interactions relevant to neurology.

Basic Information

Item	Detail
Product Name	(S)-Mephenytoin
CAS No.	70989-04-7
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	(S)-5-Ethyl-3-methyl-5-phenylhydantoin; (S)-Mephenytoin; S-Mephenytoin; (S)-Methoin; (5S)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione; (S)-Nirvanol precursor; Levomephenytoin (less common); S-Enantiomer of 5-Ethyl-3-methyl-5-phenylhydantoin
EINECS	Contact for details

Quality Control

Our (S)-Mephenytoin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay by HPLC, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.