Description

(+-)-Codeine CAS NO 70982-46-6 is a racemic mixture of the naturally occurring opiate alkaloid codeine, a key intermediate and reference standard in pharmaceutical research and development. This compound is of critical importance for its role in the synthesis and analytical validation of active pharmaceutical ingredients (APIs) and controlled substance standards. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in pain management research, method development, and quality control of narcotic preparations.

Application

• Pharmaceutical Reference Standard: Used as a primary standard in HPLC, GC, and spectroscopic assays for the quantification of codeine in bulk APIs and finished dosage forms.
• Analytical Research & Method Development: Serves as a critical material for developing and validating analytical methods in compliance with ICH, USP, and EP guidelines.
• Process Chemistry & Synthesis: Acts as a key chiral intermediate or starting material in the organic synthesis of more complex opioid derivatives and related pharmaceutical compounds.
• Forensic and Clinical Toxicology: Employed as a calibrant and control in forensic laboratories for the accurate identification and quantification of codeine in biological matrices.
• Pharmacological Studies: Utilized in in-vitro and in-vivo research to study opioid receptor binding, metabolic pathways, and the pharmacological effects of racemic codeine.
• Impurity Profiling: Essential for identifying and quantifying related substances and degradation products in codeine sulfate or phosphate bulk drug substances.

Basic Information

Product Name	(+-)-Codeine
CAS No.	70982-46-6
Molecular Formula	C18H21NO3
Molecular Weight	299.37 g/mol
Synonyms	(±)-Codeine; rac-Codeine; DL-Codeine; 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol; Morphine 3-methyl ether (racemic); 3-Methylmorphine (racemate); Methylmorphine (racemic)
EINECS	Contact for details

Quality Control

Our (+-)-Codeine is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and GC, to ensure it meets high-purity standards suitable for research and analytical applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.