Description

Di-T-Butylmethylchlorosilane is a highly reactive organosilicon compound primarily used as a versatile silylating and protecting group reagent in advanced organic synthesis. Its sterically hindered tert-butyl groups provide exceptional selectivity and stability for protecting sensitive functional groups, particularly hydroxyls, under demanding reaction conditions. This makes it a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the selective protection of hydroxyl groups in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Production: Used in creating advanced pesticide and herbicide molecules where selective silylation is required to control reactivity during synthesis.
• Peptide & Oligonucleotide Chemistry: Employed as a protecting group agent for the synthesis of peptides, nucleotides, and other biomolecules, preventing unwanted side reactions.
• Material Science & Polymer Chemistry: Serves as a precursor or modifying agent for silicon-based polymers, resins, and advanced materials requiring specific surface properties.
• Analytical Derivatization: Used to derivative polar compounds (like alcohols, phenols) for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis, improving volatility and detection.
• Organic Synthesis Research: A valuable tool in academic and industrial R&D labs for constructing complex molecular architectures, including natural products and novel heterocycles.

Basic Information

Item	Detail
Product Name	Di-T-Butylmethylchlorosilane
CAS No.	70892-81-8
Molecular Formula	C9H21ClSi
Molecular Weight	192.80 g/mol
Synonyms	Di-tert-Butylmethylchlorosilane; Di-t-Butylmethylsilyl Chloride; DTBMSCI; (Chloro)(methyl)di-tert-butylsilane; Di-tert-butylchloromethylsilane; Methyl-di-tert-butylchlorosilane; t-Bu2MeSiCl
EINECS	Contact for details

Quality Control

Our Di-T-Butylmethylchlorosilane is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including GC, NMR, and titration to ensure high purity and consistency. A detailed Certificate of Analysis (COA) confirming identity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.