Description

Mandelic-2,3,4,5,6-D5 Acid is a deuterium-labeled isotopologue of mandelic acid, where five hydrogen atoms on the aromatic ring are replaced with deuterium (CAS NO 70838-71-0). This high-purity stable isotope-labeled compound is essential as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, agrochemical, and environmental testing industries for method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Critical for precise quantification of mandelic acid and related metabolites in bioanalytical assays, drug metabolism, and pharmacokinetic (DMPK) studies.
• Pharmaceutical Research: Used in the development and validation of analytical methods for drug impurity profiling, stability testing, and ensuring batch-to-batch consistency.
• Biomarker Analysis: Enables accurate measurement of mandelic acid as a biomarker of exposure to styrene or ethylbenzene in occupational and environmental health studies.
• Metabolomics & Proteomics: Serves as a stable isotope-labeled tracer in metabolic pathway analysis and proteomic research to track biochemical processes.
• Forensic & Clinical Toxicology: Provides definitive results in toxicological screenings and forensic analyses where high specificity and accuracy are legally mandated.
• Chemical Reference Standard: Acts as a certified reference material (CRM) for calibrating instruments and verifying analytical methods in GLP/GMP-compliant laboratories.

Basic Information

Product Name	Mandelic-2,3,4,5,6-D5 Acid
CAS No.	70838-71-0
Molecular Formula	C6D5CH(OH)COOH
Molecular Weight	157.17 g/mol
Synonyms	(±)-Mandelic-2,3,4,5,6-d5 Acid; DL-Mandelic-2,3,4,5,6-d5 Acid; 2-Hydroxy-2-phenyl-d5-acetic Acid; α-Hydroxybenzene-d5-acetic Acid; Phenyl-d5-glycolic Acid; Racemic Mandelic Acid-d5; Hydroxy(phenyl-d5)acetic Acid; Benzene-d5, (hydroxyacetyl)-
EINECS	Contact for details

Quality Control

Every batch of our Mandelic-2,3,4,5,6-D5 Acid is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing batch-specific purity, isotopic purity (atom % D), and impurity profiles are provided to ensure compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.