Description

4-Aminobutyric-2,2,3,3,4,4-D6 Acid is a stable isotope-labeled analog of the essential neurotransmitter γ-aminobutyric acid (GABA), where six hydrogen atoms are replaced by deuterium. This high-purity labeled compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is indispensable for researchers and quality control laboratories in pharmaceutical development, clinical diagnostics, and neuroscience research who require precise quantification of GABA and related metabolites.

Application

• Internal Standard for LC-MS/MS & GC-MS: Primary application as a deuterated internal standard for the accurate quantification of endogenous GABA in complex biological matrices like plasma, serum, cerebrospinal fluid, and tissue homogenates.
• Pharmaceutical R&D & Bioanalysis: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to monitor drug effects on GABAergic systems and to ensure compliance with FDA/EMA bioanalytical method validation guidelines.
• Clinical Diagnostics & Metabolomics: Enables precise measurement of GABA levels for research into neurological and psychiatric disorders such as epilepsy, anxiety, depression, and schizophrenia.
• Neuroscience & Biochemical Research: Serves as a tracer in metabolic flux studies to investigate the GABA shunt and related pathways in cellular and animal models.
• Forensic & Doping Control Analysis: Supports high-confidence confirmatory testing in forensic toxicology and anti-doping programs where precise measurement of biomarker levels is legally required.
• Quality Control for Reference Materials: Used by manufacturers to certify and validate the purity and concentration of unlabeled GABA reference standards and calibrators.

Basic Information

Item	Detail
Product Name	4-Aminobutyric-2,2,3,3,4,4-D6 Acid
CAS No.	70607-85-1
Molecular Formula	C4H3D6NO2
Molecular Weight	109.15 g/mol
Synonyms	GABA-d6; γ-Aminobutyric-2,2,3,3,4,4-d6 Acid; 4-Aminobutyric-d6 Acid; (2,2,3,3,4,4-2H6)-4-Aminobutanoic Acid; 3-Carboxypropyl-d6-amine; Piperidinic-d6 Acid; Deuterated GABA; GABA Internal Standard (D6)
EINECS	Contact for details

Quality Control

Every batch of our 4-Aminobutyric-2,2,3,3,4,4-D6 Acid is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity through advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, isotopic enrichment (D-atom %), and impurity profiles to meet the stringent requirements of analytical and regulatory laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by 1H-NMR or MS)
Chemical Purity (Titration)	97.0 - 103.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.