Description

7,8-Dihydro-14-Hydroxycodeinone Acetate is a key pharmaceutical intermediate of significant importance in the synthesis of advanced opioid analgesics and related active pharmaceutical ingredients (APIs). Its precise chemical structure is critical for ensuring the efficacy and purity of the final drug products. This high-purity compound is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of potent pain management therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent opioid analgesics such as oxycodone and related derivatives.
• API Synthesis: Used in the research, development, and commercial manufacturing of Active Pharmaceutical Ingredients (APIs) for pain management.
• Medicinal Chemistry Research: Serves as a valuable precursor for structure-activity relationship (SAR) studies and the development of new therapeutic agents targeting opioid receptors.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and research laboratories for method development and impurity profiling.
• Controlled Substance Analog Synthesis: Used in authorized research for the synthesis of analogs for pharmacological evaluation.

Basic Information

Product Name	7,8-Dihydro-14-Hydroxycodeinone Acetate
CAS No.	70509-92-1
Molecular Formula	C20H23NO5
Molecular Weight	357.40 g/mol
Synonyms	14-Hydroxy-7,8-dihydrocodeinone acetate; 14-Hydroxydihydrocodeinone acetate; Dihydro-14-hydroxycodeinone acetate; 7,8-Dihydro-14-hydroxycodeinone 14-acetate; Thebaine derivative 70509-92-1; 14-Acetoxy-7,8-dihydrocodeinone; 4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one acetate
EINECS	Contact for details

Quality Control

Our 7,8-Dihydro-14-Hydroxycodeinone Acetate is manufactured under strict quality management systems to meet the exacting standards of pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure full traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.