Description

2-Propyn-1-Amine, 3-(Trimethylsilyl)- is a specialized organosilicon building block featuring a terminal alkyne and a primary amine group, protected by a trimethylsilyl (TMS) moiety. This unique bifunctional structure makes it a versatile intermediate for synthesizing complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in click chemistry (CuAAC) reactions and the development of kinase inhibitors or other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive alkyne group for structural diversification.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, dendrimers, and silicon-containing advanced materials.
• Bioconjugation & Probe Synthesis: Utilized in chemical biology for labeling biomolecules (proteins, peptides, nucleic acids) via its amine and alkyne functionalities to create diagnostic probes or drug conjugates.
• Organic Synthesis Reagent: Acts as a protected propargylamine equivalent in multi-step synthetic routes, including heterocycle formation and natural product synthesis.

Basic Information

Product Name	2-Propyn-1-Amine, 3-(Trimethylsilyl)-
CAS No.	70052-55-0
Molecular Formula	C6H13NSi
Molecular Weight	127.26 g/mol
Synonyms	3-(Trimethylsilyl)prop-2-yn-1-amine; (3-Trimethylsilyl-2-propynyl)amine; 3-(Trimethylsilyl)propargylamine; N-(3-Trimethylsilyl-2-propynyl)amine; TMS-Propargylamine; Trimethyl(3-aminoprop-1-yn-1-yl)silane; 1-Amino-3-trimethylsilyl-2-propyne
EINECS	Contact for details

Quality Control

Our 2-Propyn-1-Amine, 3-(Trimethylsilyl)- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality systems are designed to meet the stringent requirements of research and cGMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.