Description

Metoprine CAS NO 7761-45-7 is a specialized chemical compound belonging to the class of diaminopyrimidines, primarily recognized for its role as a potent inhibitor of dihydrofolate reductase (DHFR). This mechanism of action makes it a valuable tool in biochemical research and a key intermediate in the synthesis of more complex therapeutic agents. It is essential for pharmaceutical R&D laboratories, agrochemical innovators, and academic institutions focused on enzymology, parasitology, and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced dihydrofolate reductase inhibitors and other antiparasitic or antineoplastic compounds.
• Biochemical Research: Used as a reference standard and inhibitor in enzymatic studies to investigate folate metabolism pathways and cellular proliferation mechanisms.
• Agrochemical Development: Serves as a precursor or model compound in the research and development of novel herbicides or fungicides targeting specific enzymatic processes in plants and pests.
• Veterinary Medicine Research: Investigated for potential applications in developing treatments for parasitic infections in animals.
• Academic & Contract Research: Employed in university and CRO settings for fundamental life science research and high-throughput screening assays.

Basic Information

Product Name	Metoprine
CAS No.	7761-45-7
Molecular Formula	C14H18N4O
Molecular Weight	258.32 g/mol
Synonyms	2,4-Diamino-5-(3,4-dichlorobenzyl)pyrimidine; BW 197U; DDMP; Metoprin; Methoprine; 5-[(3,4-Dichlorophenyl)methyl]-2,4-pyrimidinediamine; NSC 113092; 7761-45-7
EINECS	231-830-9

Quality Control

Our Metoprine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.