Description

3-Maleimidopropionic Acid is a versatile heterobifunctional crosslinking agent featuring a maleimide group and a carboxylic acid group. This molecular architecture is critical for creating stable covalent bonds with thiols while offering a convenient handle for further conjugation via its carboxylate. It is an essential building block for researchers and manufacturers in the bioconjugation and materials science fields, enabling the precise modification of proteins, peptides, polymers, and surfaces.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: A key reagent for site-specific coupling of cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, and peptides via thiol-maleimide chemistry.
• Polymer and Hydrogel Synthesis: Used as a functional monomer or crosslinker to introduce reactive maleimide sites into polymer backbones or to create smart, responsive hydrogel networks.
• Surface Functionalization: Enables the covalent immobilization of biomolecules (e.g., proteins, DNA) onto carboxylated surfaces, chips, or nanoparticles for biosensor and diagnostic assay development.
• Peptide and Protein Modification: Facilitates the labeling, PEGylation, or structural stabilization of biomolecules by reacting with cysteine residues.
• Materials Science Research: Serves as a fundamental tool for creating novel functional materials with tailored chemical and physical properties through controlled crosslinking reactions.

Basic Information

Product Name	3-Maleimidopropionic Acid
CAS No.	7423-55-4
Molecular Formula	C7H7NO4
Molecular Weight	169.13 g/mol
Synonyms	3-Maleimidopropanoic Acid; Maleimidopropionic Acid; 3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)propanoic Acid; 1-(2-Carboxyethyl)-1H-pyrrole-2,5-dione; β-Maleimidopropionic Acid; N-(2-Carboxyethyl)maleimide; 3-MPA; MPA; 3-Maleimidopropionic Acid CAS NO 7423-55-4
EINECS	231-056-1

Quality Control

Our 3-Maleimidopropionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.