Description

(R)-1,2,3,4-Tetrahydro-8-Hydroxy-7-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2,2-Dimethylisoquinolin-2-Ium CAS NO 7354-32-7 is a high-purity, chiral isoquinolinium derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate for synthesizing complex molecules with potential biological activity. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring stereochemical specificity.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) or cardiovascular targets.
• Asymmetric Synthesis: Utilized in research-scale asymmetric synthesis to construct complex molecular architectures with defined stereochemistry.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of new chemical entities.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Biochemical Research: Potential tool compound for investigating biological pathways and receptor interactions in academic and industrial settings.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for advanced pharmaceutical intermediates.

Basic Information

Product Name	(R)-1,2,3,4-Tetrahydro-8-Hydroxy-7-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2,2-Dimethylisoquinolin-2-Ium
CAS No.	7354-32-7
Molecular Formula	C₂₁H₂₇NO₃⁺
Molecular Weight	341.45 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydro-8-hydroxy-7-methoxy-1-[(4-methoxyphenyl)methyl]-2,2-dimethylisoquinolin-2-ium; (R)-THIQ derivative; (R)-8-Hydroxy-7-methoxy-1-(4-methoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-ium; (R)-1-(4-Methoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydro-8-hydroxy-7-methoxyisoquinolin-2-ium; (R)-N-Methylcorydine derivative; (R)-Isoquinolinium salt; (R)-1,2,3,4-Tetrahydroisoquinoline alkaloid analog
EINECS	Contact for details

Quality Control

Our production of (R)-1,2,3,4-Tetrahydro-8-Hydroxy-7-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2,2-Dimethylisoquinolin-2-Ium adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific analytical results (including chiral purity by HPLC) are provided with every shipment. We support compliance with relevant ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (R-enantiomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.