Description

2-Methoxyphenol-3,4,5,6-D4 is a deuterium-labeled isotopologue of guaiacol, a naturally occurring organic compound, where four hydrogen atoms are replaced with deuterium at the 3, 4, 5, and 6 positions of the aromatic ring. This isotopic labeling is critical for applications requiring high precision in analytical and research methodologies, as it provides a stable, non-radioactive internal standard. It is an essential material for scientists and quality control professionals in the pharmaceutical, agrochemical, and analytical chemistry industries who require definitive compound identification and accurate quantification.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a stable, isotopically labeled reference compound in GC-MS and LC-MS analyses for the accurate quantification of guaiacol and related phenolic compounds in complex matrices.
• Metabolic Pathway Tracing: Employed in pharmacokinetic and drug metabolism studies to trace the biological pathways and biotransformation of phenolic compounds without interference from endogenous substances.
• Pharmaceutical Impurity Profiling: Serves as a critical tool in the development and validation of analytical methods for identifying and quantifying impurities and degradants in active pharmaceutical ingredients (APIs).
• Flavor and Fragrance Research: Acts as a deuterated standard in the analysis of natural products, essential oils, and food products where guaiacol is a key aroma component (e.g., smoke flavoring, vanilla).
• Environmental Analysis: Utilized in the detection and quantification of phenolic pollutants, such as those from wood smoke or industrial processes, in environmental samples like water and air.
• Synthetic Chemistry & NMR Spectroscopy: Provides a useful probe in mechanistic studies and as a building block in the synthesis of deuterated complex molecules for nuclear magnetic resonance (NMR) applications.

Basic Information

Product Name	2-Methoxyphenol-3,4,5,6-D4
CAS No.	7329-52-4
Molecular Formula	C7H4D4O2
Molecular Weight	128.16 g/mol
Synonyms	Guaiacol-d4; 2-Methoxyphenol-d4; 1-Hydroxy-2-methoxybenzene-3,4,5,6-d4; o-Methoxyphenol-d4; Methylcatechol-d4 (ambiguous); Deuterated Guaiacol; [3,4,5,6-2H4]-2-Methoxyphenol
EINECS	Contact for details

Quality Control

Every batch of our 2-Methoxyphenol-3,4,5,6-D4 is produced and tested under strict quality management systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) that detail key parameters including isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation by spectroscopic methods. Our quality commitment aligns with the rigorous standards expected in pharmaceutical and high-end research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to maximize shelf-life and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.