Description

2-[4-[Bis[(2,5-Dioxopyrrole-1-Carbonyl)Amino]Methyl]Phenoxy]Acetic Acid is a specialized bifunctional linker molecule featuring two reactive maleimide (dioxopyrrole) groups and a carboxylic acid terminus. This compound matters for its ability to create stable, covalent bonds with thiol groups, making it an essential tool for precise bioconjugation and cross-linking applications. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing antibody-drug conjugates (ADCs), protein modifications, and advanced polymer materials.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable, or non-cleavable linkers connecting cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: Used for site-specific labeling of cysteine residues in proteins, enabling the attachment of fluorophores, drugs, or other functional molecules.
• Surface Functionalization: Immobilization of biomolecules onto solid supports (e.g., sensor chips, nanoparticles, beads) via thiol-maleimide chemistry for biosensing and assay development.
• Polymer Cross-linking Agent: Serves as a cross-linker in the synthesis of hydrogels and functional polymers with tailored mechanical and biological properties.
• Bioconjugation Reagent: Facilitates the creation of stable thioether bonds between diverse molecules in diagnostic kit components and research tools.
• Intermediate for Specialty Chemicals: A building block for synthesizing more complex heterobifunctional or multifunctional cross-linkers used in advanced life science research.

Basic Information

Product Name	2-[4-[Bis[(2,5-Dioxopyrrole-1-Carbonyl)Amino]Methyl]Phenoxy]Acetic Acid
CAS No.	7253-21-6
Molecular Formula	C20H16N4O9
Molecular Weight	456.36 g/mol
Synonyms	Bis-Maleimidoacetic Acid; BMAA; 4-[(Bis(2,5-dioxo-1H-pyrrol-1-yl)methyl)phenoxy]acetic Acid; 1,1'-[4-(Carboxymethoxy)phenyl]methanediylbis(1H-pyrrole-2,5-dione); Maleimide-PEG1-Acid; Bifunctional Maleimide Linker; (4-((Bis(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)phenoxy)acetic Acid; N,N'-(4-(Carboxymethoxy)benzyl)dimaleimide
EINECS	Contact for details

Quality Control

Our 2-[4-[Bis[(2,5-Dioxopyrrole-1-Carbonyl)Amino]Methyl]Phenoxy]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.