Description

14-Hydroxydihydrocodeine is a semi-synthetic opioid derivative and a key pharmaceutical intermediate. This compound is valued for its role in the synthesis of more complex analgesic and antitussive agents, offering a critical building block for advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in the production of controlled substance APIs and reference standards.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of advanced opioid analgesics and specialized antitussive medications.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical products.
• Research & Development: Serves as a key starting material in medicinal chemistry for exploring new derivatives with modified pharmacological profiles.
• Controlled Substance Synthesis: Employed in the licensed, regulated production of Schedule II and III narcotic substances for medical use.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway research for codeine and related opioids.

Basic Information

Product Name	14-Hydroxydihydrocodeine
CAS No.	7183-69-9
Molecular Formula	C18H23NO4
Molecular Weight	317.38 g/mol
Synonyms	14-Hydroxydihydrocodeine; Dihydro-14-hydroxycodeine; 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6α,14-diol; 14-Hydroxycodeinone Dihydro Derivative; 6α,14-Dihydroxy-3-methoxy-17-methyl-4,5α-epoxymorphinan; Norcodeinone Dihydro-14-ol; 14-Hydroxydihydrocodeine Base
EINECS	Contact for details

Quality Control

Our 14-Hydroxydihydrocodeine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, identification by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.