Description

Acetonitrile, [1-14C] is a carbon-14 labeled isotopologue of acetonitrile, a fundamental polar aprotic solvent and versatile chemical building block. This radiolabeled compound is essential for precise metabolic and pharmacokinetic studies, enabling researchers to trace the fate of acetonitrile-derived moieties in complex biological and chemical systems. It is a critical reagent for scientists in pharmaceutical R&D, agrochemical development, and environmental analysis who require high-specific-activity materials for autoradiography, liquid scintillation counting, and advanced analytical techniques.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used to investigate the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities in preclinical studies.
• Mechanistic Organic Chemistry Research: Serves as a labeled reagent to elucidate reaction pathways and mechanisms, particularly in nitrile and cyano-group transformations.
• Environmental Fate and Metabolism Studies: Employed to track the degradation pathways and environmental persistence of acetonitrile and related compounds.
• Synthesis of Labeled Pharmaceutical Intermediates: Acts as a 14C-labeled synthon for the preparation of more complex radiolabeled molecules for clinical trials.
• Quality Control in HPLC Method Development: Can be used as a traceable standard in the calibration of analytical equipment, including liquid chromatography systems.

Basic Information

Product Name	Acetonitrile, [1-14C]
CAS No.	7183-56-4
Molecular Formula	C14CH3N or CH3C14N
Molecular Weight	~42.04 g/mol (varies with specific activity)
Synonyms	Acetonitrile-1-14C; Methyl cyanide-1-14C; Ethanenitrile-1-14C; Cyanomethane-1-14C; ACN-1-14C; [1-14C]Acetonitrile; Acetonitrile (carbon-14 labeled); Radiolabeled acetonitrile
EINECS	Contact for details

Quality Control

Every batch of Acetonitrile, [1-14C] is manufactured and analyzed under strict quality systems to ensure high chemical, radiochemical, and isotopic purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on specific activity, radiochemical purity (typically by radio-HPLC or TLC), chemical purity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. Due to its highly volatile nature, ensure containers are securely sealed and stored in a well-ventilated, dedicated radiolabeled storage area in compliance with all local and international regulations for radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless solution
Identification (IR)	Conforms to structure
Specific Activity	Contact for details (mCi/mmol)
Radiochemical Purity (Radiometric HPLC)	≥ 98%
Chemical Purity (HPLC/GC)	≥ 99%
Solvent	Specified on COA (e.g., Acetonitrile, Toluene)
Concentration	Specified on COA (mCi/mL or MBq/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.