Description

Cinnarizine-D8 2Hcl is a deuterium-labeled analog of the pharmaceutical compound Cinnarizine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control testing.

Application

• Internal Standard for Bioanalysis: Essential for the precise quantification of Cinnarizine in complex biological matrices (e.g., plasma, serum, urine) using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to track the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Pharmaceutical Quality Control: Serves as a critical reference standard in the assay and impurity profiling of Cinnarizine active pharmaceutical ingredients (APIs) and finished dosage forms.
• Clinical Research: Supports the bioanalytical component of clinical trials to ensure data integrity and regulatory compliance.
• Forensic and Toxicology Testing: Aids in the accurate detection and measurement of Cinnarizine in forensic investigations.
• Method Development and Validation: A key tool for scientists developing and validating robust, sensitive, and specific analytical methods.

Basic Information

Product Name	Cinnarizine-D8 2Hcl
CAS No.	7002-58-6
Molecular Formula	C26H20D8Cl2N2
Molecular Weight	447.45 g/mol
Synonyms	1-(Diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)-piperazine-d8 Dihydrochloride; Cinnarizine-d8 Dihydrochloride; Cinnarizine (phenyl-d8) Dihydrochloride; 1-Benzhydryl-4-cinnamylpiperazine-d8 Dihydrochloride; (±)-Cinnarizine-d8 2HCl; Cinnipirine-d8 Dihydrochloride; Stugeron-d8 Dihydrochloride; Mitronal-d8 Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of Cinnarizine-D8 2Hcl is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including deuterium enrichment (chemical and isotopic purity), assay by HPLC, and residual solvent content. Our quality commitment ensures traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chemical Purity (by HPLC)	≥99.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.