Description

(-)-Dihydroisocodeine is a semi-synthetic opioid alkaloid derived from thebaine, serving as a key chiral intermediate in advanced pharmaceutical synthesis. This compound is of significant value for research and development in medicinal chemistry, particularly for creating novel analgesics and studying opioid receptor pharmacology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on controlled substance synthesis and neuropharmacology.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of more complex opioid derivatives and potential therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new analgesics with improved efficacy and reduced side-effect profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and forensic analysis in laboratories.
• Biochemical Research: Employed in in vitro studies to investigate the binding affinity and functional activity at mu, delta, and kappa opioid receptors.
• Process Development: Utilized in scaling up and optimizing synthetic routes for opioid-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(-)-Dihydroisocodeine
CAS No.	795-38-0
Molecular Formula	C₁₈H₂₃NO₃
Molecular Weight	301.38 g/mol
Synonyms	(-)-Dihydroisocodeine; Dihydroisocodeine; 7,8-Dihydroisocodeine; 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6α-ol; Isocodeine Dihydro Derivative; (5α,6α)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
EINECS	Contact for details

Quality Control

Our (-)-Dihydroisocodeine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, and NMR. We adhere to cGMP principles where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.