Description

2-Chloro-5-Trifluoroacetylthiophene is a high-value, multi-functional chemical building block characterized by its reactive trifluoroacetyl and chloro substituents on a thiophene ring. This compound is essential for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought after by research and development chemists, process scale-up engineers, and manufacturers in fine chemical and advanced material industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for enhanced efficacy.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of novel conductive polymers and organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create specialized ligands for catalytic processes.
• Fluorochemical Building Block: The trifluoroacetyl group makes it a valuable starting material for introducing fluorine atoms into target molecules to modify their properties.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences and specialty chemical markets.

Basic Information

Product Name	2-Chloro-5-Trifluoroacetylthiophene
CAS No.	771-83-5
Molecular Formula	C6H2ClF3OS
Molecular Weight	214.59 g/mol
Synonyms	2-Chloro-5-(trifluoroacetyl)thiophene; 1-(5-Chloro-2-thienyl)-2,2,2-trifluoroethanone; 2-Chloro-α,α,α-trifluoro-2-thiopheneacetyl; 5-Chloro-2-thenoyltrifluoride; 5-Chloro-2-thienyl trifluoromethyl ketone; 2-Chloro-5-(trifluoroacetyl)thiophene; 2-Chloro-5-trifluoroacetythiophene; 2-Chloro-5-trifluoroacetylthiophene
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Trifluoroacetylthiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.