Description

Halothane-D CAS NO 754-19-8 is a deuterated analog of the widely used inhalation anesthetic, Halothane. This stable isotope-labeled compound is essential for advanced research and analytical applications requiring precise molecular tracking. It is primarily utilized by pharmaceutical researchers, analytical chemists, and manufacturers of reference standards. Its high purity and isotopic enrichment make it a critical tool for pharmacokinetic studies, metabolic pathway elucidation, and internal standard calibration in mass spectrometry.

Application

• Internal Standard for Analytical Chemistry: Used as a deuterated internal standard in Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) for the accurate quantification of Halothane and its metabolites in complex biological matrices.
• Metabolic and Pharmacokinetic Research: Enables detailed studies of drug metabolism, distribution, and excretion (DMPK) by tracing the deuterium label, helping to understand the fate of Halothane in biological systems.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for method development, validation, and quality control in pharmaceutical laboratories and regulatory testing.
• Isotope Dilution Mass Spectrometry (IDMS): Critical for high-precision, definitive methods in clinical toxicology and forensic analysis to ensure accurate and legally defensible results.
• Biochemical Pathway Tracing: Facilitates research into enzymatic mechanisms and biochemical interactions involving halogenated hydrocarbons.
• Environmental Fate Studies: Assists in tracing the environmental degradation and transformation pathways of volatile anesthetic agents.

Basic Information

Product Name	Halothane-D
CAS No.	754-19-8
Molecular Formula	C2HBrClF3D
Molecular Weight	198.38 g/mol (for monodeuterated form)
Synonyms	2-Bromo-2-chloro-1,1,1-trifluoroethane-d; Deuterated Halothane; Halothane-d1; 2-Bromo-2-chloro-1,1,1-trifluoroethane (deuterated); Fluothane-D; NSC 151912-d; RCRA waste number U044 (deuterated form); Anesthetic Halothane Deuterated
EINECS	Contact for details

Quality Control

Every batch of Halothane-D is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (D-enrichment), chemical purity by GC, and identity confirmation by NMR and IR spectroscopy. Our quality commitment ensures the material meets the stringent requirements for research and analytical applications, supporting compliance with GLP and ISO 17025 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, ideally at controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use to prevent loss and maintain purity.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.1%
Residue on Evaporation	≤ 0.01%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.