Description

4-[(2R,5S,6E)-2-Hydroxy-5,7-Dimethyl-4-Oxo-Nona-6,8-Dienyl]Piperidine- 2,6-Dione is a high-purity, structurally complex chiral compound that serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis. Its unique molecular architecture, featuring a piperidine-2,6-dione core and a functionalized dienyl side chain, makes it invaluable for the research and development of novel active pharmaceutical ingredients (APIs). This compound is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, particularly in oncology and neurology research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) due to its reactive functional groups.
• Asymmetric Synthesis: Serves as a precursor or template in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial drug production.
• Bioconjugation & Prodrug Synthesis: Its functional groups allow for conjugation strategies to improve drug solubility, targeting, or pharmacokinetic profiles.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	4-[(2R,5S,6E)-2-Hydroxy-5,7-Dimethyl-4-Oxo-Nona-6,8-Dienyl]Piperidine- 2,6-Dione
CAS No.	738-72-7
Molecular Formula	C19H29NO4
Molecular Weight	335.44 g/mol
Synonyms	(2R,5S,6E)-2-Hydroxy-5,7-dimethyl-4-oxonona-6,8-dien-1-yl-2,6-dioxopiperidine; 4-[(2R,5S,6E)-2-Hydroxy-5,7-dimethyl-4-oxonona-6,8-dien-1-yl]piperidine-2,6-dione; 2,6-Piperidinedione, 4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-6,8-nonadienyl]-; (2R,5S,6E)-2-Hydroxy-5,7-dimethyl-4-oxonona-6,8-dienoic acid 2,6-dioxopiperidin-4-yl ester (tautomeric form).
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Every lot is characterized and released based on comprehensive analytical testing, including chiral purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support our partners with full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to moisture and air; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.