Description

2-Difluoromethyl-1H-Benzoimidazole CAS NO 705-09-9 is a specialized fluorinated heterocyclic compound belonging to the benzimidazole class. This high-value intermediate is critical for the synthesis of advanced pharmaceuticals and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity and metabolic stability. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in antiviral, anticancer, and anti-inflammatory research programs.
• Agrochemical Synthesis: Used in the development of next-generation fungicides, herbicides, and pesticides, where the difluoromethyl group enhances efficacy and environmental profile.
• Material Science Research: Serves as a precursor for advanced organic electronic materials, ligands for catalysis, and specialty polymers.
• Chemical Biology & Proteomics: Employed as a reactive handle or probe in the study of enzyme mechanisms and protein labeling.
• Organic Synthesis: A versatile reagent for introducing the difluoromethyl-benzimidazole moiety into complex molecular architectures.

Basic Information

Product Name	2-Difluoromethyl-1H-Benzoimidazole
CAS No.	705-09-9
Molecular Formula	C8H6F2N2
Molecular Weight	168.15 g/mol
Synonyms	2-(Difluoromethyl)-1H-benzimidazole; 1H-Benzimidazole, 2-(difluoromethyl)-; 2-(Difluoromethyl)benzimidazole; Benzimidazole, 2-(difluoromethyl)-; Difluoromethylbenzimidazole; 705-09-9; NSC 406170
EINECS	Contact for details

Quality Control

Our 2-Difluoromethyl-1H-Benzoimidazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.