Description

Tetramethylsilane (TMS) is a fundamental organosilicon compound and a cornerstone reagent in analytical chemistry. Its primary value lies in its role as the universal chemical shift reference standard for Nuclear Magnetic Resonance (NMR) spectroscopy, providing a critical benchmark for precise molecular structure determination. This high-purity chemical is essential for R&D and quality control laboratories across the pharmaceutical, polymer, and academic research sectors, where accurate spectral data is non-negotiable.

Application

• NMR Spectroscopy Reference Standard: The predominant application as an internal chemical shift reference (0 ppm) for ¹H, ¹³C, and ²⁹Si NMR in both solution and solid-state analysis.
• Silicon Chemistry & Precursor: Serves as a key starting material and precursor in the synthesis of more complex organosilicon compounds, silicones, and silicon-based polymers.
• Chemical Vapor Deposition (CVD): Used as a silicon source in CVD processes for depositing silicon-containing thin films and coatings in semiconductor and optics manufacturing.
• Reagent for Derivatization: Employed in analytical procedures to derivative compounds for gas chromatography (GC) or other separation techniques, improving volatility and detection.
• Solvent & Reaction Medium: Functions as a non-polar, inert solvent for specific organic and organometallic reactions.
• Calibration & Instrumentation: Used for calibrating instruments and validating NMR spectrometer performance due to its sharp, well-defined singlet peak.

Basic Information

Product Name	Tetramethylsilane
CAS No.	75-76-3
Molecular Formula	C4H12Si
Molecular Weight	88.22 g/mol
Synonyms	TMS; Tetramethylsilicon; Silane, tetramethyl-; NMR Grade Tetramethylsilane; Silicon tetramethyl; NSC 68473; UN 2749; 1,1,1,1-Tetramethylsilane
EINECS	200-899-1

Quality Control

Our Tetramethylsilane is produced and handled under stringent quality management systems to ensure batch-to-batch consistency and reliability for sensitive analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles. We offer various grades, including high-purity NMR spectroscopic grade, tailored to meet the exacting requirements of research and industrial laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat, sparks, and open flames. Due to its highly volatile nature, containers must be kept tightly sealed when not in use to prevent evaporation and maintain purity. Recommended storage temperature is 2-8°C (refrigerated) for extended stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
NMR Purity (¹H NMR)	Single sharp peak at 0.0 ppm, free of extraneous signals
Density at 20°C	0.648 - 0.652 g/mL
Refractive Index (n20D)	1.358 - 1.360
Boiling Point	26 - 27°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.