Description

Adipic-1,6-13C2 Acid is a stable isotope-labeled analog of adipic acid, where two carbon atoms at the 1 and 6 positions are replaced with the 13C isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry and NMR spectroscopy, providing unparalleled accuracy in metabolic and pharmacokinetic studies. It is a critical material for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require precise isotopic labeling for tracer experiments and method validation.

Application

• Quantitative Mass Spectrometry (MS): Serves as a high-purity internal standard for the accurate quantification of adipic acid and related metabolites in complex biological matrices.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Used as a 13C-labeled tracer to elucidate metabolic pathways and study reaction mechanisms without signal interference from natural abundance carbon.
• Pharmaceutical Research & Development: Critical in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug compounds and their metabolites in vivo.
• Biochemical Research: Enables detailed investigation of fatty acid metabolism, the citric acid cycle, and other biochemical processes involving dicarboxylic acids.
• Analytical Method Development: Used to validate and calibrate analytical methods (LC-MS, GC-MS) for enhanced specificity and reliability in testing laboratories.
• Industrial Process Monitoring: Can be employed as a tracer in chemical manufacturing processes to study efficiency, yield, and byproduct formation.

Basic Information

Product Name	Adipic-1,6-13C2 Acid
CAS No.	133954-44-6
Molecular Formula	13C2H10O4
Molecular Weight	148.12 g/mol (for 13C2 labeled form)
Synonyms	1,6-13C2-Adipic Acid; Hexanedioic-1,6-13C2 Acid; [1,6-13C2]Adipic Acid; 13C Labeled Adipic Acid; Isotopic Adipic Acid; Adipic Acid-13C2; 13C2-Adipic Acid; Dicarboxylic Acid-13C2 Standard
EINECS	Contact for details

Quality Control

Our Adipic-1,6-13C2 Acid is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is analyzed to confirm identity, isotopic enrichment (typically >99 atom % 13C), and chemical purity (often >98%). A comprehensive Certificate of Analysis (COA) is provided, detailing results from tests including NMR, MS, and HPLC. We support compliance with relevant GLP and ISO 9001 standards for reliable and traceable material sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. The product is hygroscopic (moisture-sensitive) and should be kept under inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.