Description

1H-Indole, 3-[[4-[4-(Trifluoromethyl)-2-Pyridinyl]-1-Piperazinyl]Methyl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel, biologically active molecules, particularly in central nervous system (CNS) and oncology research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to develop next-generation therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates targeting specific receptors.
• Biochemical Research: Used as a reference standard or active probe in pharmacological and neurological studies.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses to construct sophisticated indole- and piperazine-containing frameworks.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry and heterocyclic chemistry exploration.
• Agrochemical Research: Potential application as an intermediate in the development of new active ingredients, given its structural features.

Basic Information

Product Name	1H-Indole, 3-[[4-[4-(Trifluoromethyl)-2-Pyridinyl]-1-Piperazinyl]Methyl]-
CAS No.	698973-99-8
Molecular Formula	C19H19F3N4
Molecular Weight	360.38 g/mol
Synonyms	3-[[4-[4-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-indole; 1H-Indole-3-methanol, α-[4-[4-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]methyl]-; (3-((4-(4-(Trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methyl)-1H-indole); Trifluoromethylpyridinylpiperazinylmethylindole; Advanced Indole-Piperazine Intermediate; TFPI; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our production of 1H-Indole, 3-[[4-[4-(Trifluoromethyl)-2-Pyridinyl]-1-Piperazinyl]Methyl]- adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.