Description

3-(Methyl-D3)-1H-Indole-2,4,5,6,7-D5 is a high-purity, multi-deuterated isotopologue of 3-methylindole, a key heterocyclic compound. This stable isotope-labeled material is essential for advanced analytical applications where high mass resolution and minimal background interference are critical. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for applications such as internal standards in mass spectrometry and mechanistic studies in drug metabolism.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis for pharmacokinetic, metabolomic, and environmental testing.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the metabolic pathways and bioavailability of pharmaceutical compounds.
• NMR Spectroscopy: Acts as a deuterated solvent or shift reference in nuclear magnetic resonance studies due to its specific isotopic labeling.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Employed in the development and analysis of deuterated agrochemicals and their environmental fate.
• Mechanistic Organic Chemistry: Utilized as a probe in kinetic isotope effect (KIE) studies to elucidate reaction mechanisms.

Basic Information

Product Name	3-(Methyl-D3)-1H-Indole-2,4,5,6,7-D5
CAS No.	697807-03-7
Molecular Formula	C9H2D8N
Molecular Weight	139.24 g/mol
Synonyms	3-(Trideuteriomethyl)-1H-indole-2,4,5,6,7-pentadeuterio; 3-Methyl-D3-indole-2,4,5,6,7-D5; Perdeuterated 3-Methylindole (partial); Skatole-d8; 3-Methyl-1H-indole-d8; 2,4,5,6,7-Pentadeutero-3-(trideuteriomethyl)-1H-indole; 3-(Methyl-d3)indole-2,4,5,6,7-d5
EINECS	Contact for details

Quality Control

Every batch of 3-(Methyl-D3)-1H-Indole-2,4,5,6,7-D5 is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed under an inert atmosphere if prolonged storage is required to maintain isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.