Description

2-Chloro-6-Methoxypyridine-4-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific pyridine-based architectures.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology Probes: Serves as a building block for creating labeled compounds and molecular probes used in biochemical assays and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity boronic esters.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new catalytic processes in academic and industrial laboratories.

Basic Information

Product Name	2-Chloro-6-Methoxypyridine-4-Boronic Acid Pinacol Ester
CAS No.	697739-24-5
Molecular Formula	C₁₂H₁₇BClNO₃
Molecular Weight	269.53 g/mol
Synonyms	2-Chloro-6-methoxypyridine-4-boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2-chloro-6-methoxypyridin-4-yl)-1,3,2-dioxaborolane; (2-Chloro-6-methoxypyridin-4-yl)boronic acid pinacol ester; 2-Chloro-6-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol (2-chloro-6-methoxypyridin-4-yl)boronate
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Methoxypyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.