Description

R-3,3'-Bis(Phenyl)-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate is a high-value, chiral organophosphorus compound widely recognized as a privileged ligand and catalyst in asymmetric synthesis. Its core value lies in its ability to induce high enantioselectivity in a variety of critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the production of single-enantiomer intermediates. This product is essential for research and development laboratories, as well as production facilities in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemical control is paramount for developing new active ingredients and advanced materials.

Application

• Asymmetric Catalysis: Serves as a highly effective chiral ligand for transition metal-catalyzed reactions, including asymmetric hydrogenation, cross-coupling, and allylic substitution.
• Pharmaceutical Intermediate Synthesis: Critical for the enantioselective synthesis of chiral drug candidates and active pharmaceutical ingredients (APIs), such as kinase inhibitors and antiviral agents.
• Agrochemical Development: Used in the research and production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Chiral Auxiliary & Resolving Agent: Employed in the resolution of racemic mixtures and as a building block for other chiral phosphoric acid catalysts and ligands.
• Material Science Research: Investigated for applications in chiral polymers, liquid crystals, and molecular recognition systems.
• Academic & Process Chemistry: A fundamental tool for methodological development in organic chemistry and for scaling up asymmetric transformations.

Basic Information

Product Name	R-3,3'-Bis(Phenyl)-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate
CAS No.	695162-86-8
Molecular Formula	C32H21O4P
Molecular Weight	500.48 g/mol
Synonyms	(R)-3,3'-Diphenyl-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; (R)-3,3'-Diphenyl-BINOL phosphate; (R)-VAPOL Phosphoric Acid; (R)-3,3'-Bis(phenyl)-[1,1'-binaphthalene]-2,2'-diyl hydrogen phosphate; (R)-VAPOL-HPA; R-VAPOL-PA; (R)-VAPOL Phosphoric Acid Catalyst; R-3,3'-Diphenyl-2,2'-dihydroxy-1,1'-binaphthyl phosphate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity chiral chemicals. Each batch is characterized using advanced analytical techniques to confirm identity, chiral purity (enantiomeric excess), and chemical purity. Certificates of Analysis (COA) are provided, detailing key parameters such as assay, enantiomeric excess (by chiral HPLC or SFC), and impurity profiles. We adhere to strict quality management protocols to ensure batch-to-batch consistency and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/SFC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.