Description

4-(1H-Indol-5-Yl)-Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture that combines indole and benzonitrile moieties. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small molecule drugs, particularly for oncology and central nervous system (CNS) applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting specific protein receptors.
• Kinase Inhibitor Research: Used in the development and optimization of potent kinase inhibitors for cancer therapy.
• CNS Drug Discovery: Serves as a core scaffold for compounds targeting neurological pathways and disorders.
• Agrochemical Research: Potential intermediate for creating new active ingredients with specific biological activity.
• Material Science: Investigated as a monomer or precursor for functional organic materials and polymers.
• Academic & Contract Research: Utilized in universities and CROs for method development and structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-(1H-Indol-5-Yl)-Benzonitrile
CAS No.	694533-08-9
Molecular Formula	C15H10N2
Molecular Weight	218.26 g/mol
Synonyms	5-(4-Cyanophenyl)-1H-indole; 4-(5-Indolyl)benzonitrile; 1H-Indole-5-carbonitrile, 4-phenyl-; Benzonitrile, 4-(1H-indol-5-yl)-; 694533-08-9; 4-Indol-5-yl-benzonitrile; 5-(4-Cyanophenyl)indole
EINECS	Contact for details

Quality Control

Our 4-(1H-Indol-5-Yl)-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our standard is to supply material with a typical purity of ≥97% (HPLC), with higher grades available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.