Description

(E)-1-[3,4-Dihydro-2(1H)-Isoquinolinyl]-4,4,5,5,5-Pentafluoro-1-Penten-3-One is a high-value, structurally complex fluorinated organic compound featuring an isoquinoline moiety. This molecule is significant for its role as a versatile synthetic intermediate in advanced pharmaceutical and agrochemical research, where the introduction of pentafluorinated groups can dramatically alter biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the fluorine atoms enhance lipophilicity and environmental stability.
• Fluorine Chemistry: Serves as a valuable substrate for studying fluorination reactions and creating fluorinated analogs of bioactive molecules.
• Material Science Precursor: Potential intermediate for synthesizing specialty polymers or liquid crystals with unique electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(E)-1-[3,4-Dihydro-2(1H)-Isoquinolinyl]-4,4,5,5,5-Pentafluoro-1-Penten-3-One
CAS No.	692738-20-8
Molecular Formula	C₁₄H₁₂F₅NO
Molecular Weight	305.25 g/mol
Synonyms	(E)-1-(3,4-Dihydroisoquinolin-2(1H)-yl)-4,4,5,5,5-pentafluoropent-1-en-3-one; 1-(3,4-Dihydro-2(1H)-isoquinolinyl)-4,4,5,5,5-pentafluoro-1-penten-3-one; 2-[(1E)-4,4,5,5,5-Pentafluoro-3-oxo-1-penten-1-yl]-1,2,3,4-tetrahydroisoquinoline; Pentafluorinated Isoquinoline Enone; PFIQ Enone
EINECS	Contact for details

Quality Control

Our (E)-1-[3,4-Dihydro-2(1H)-Isoquinolinyl]-4,4,5,5,5-Pentafluoro-1-Penten-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.