Description

(E)-3-[4-(3-Formyl-1H-Indol-1-Yl)Phenyl]-2-(2-Thienyl)-2-Propenenitrile is a high-purity, advanced pharmaceutical intermediate with a complex molecular architecture. This compound matters as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the discovery of new therapeutic agents, especially those targeting specific enzymatic pathways or receptor sites.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• Organic Light-Emitting Diode (OLED) Materials: Functions as an electron-transport or emissive layer material in the development of advanced OLED displays and lighting, leveraging its conjugated system.
• Agrochemical Synthesis: Employed in the research and development of novel pesticides or herbicides, where its heterocyclic components can impart specific biological activity.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists exploring new reactions, catalytic processes, or the development of functional materials.

Basic Information

Product Name	(E)-3-[4-(3-Formyl-1H-Indol-1-Yl)Phenyl]-2-(2-Thienyl)-2-Propenenitrile
CAS No.	692287-44-8
Molecular Formula	C22H14N2OS
Molecular Weight	354.43 g/mol
Synonyms	(E)-3-[4-(3-Formyl-1H-indol-1-yl)phenyl]-2-(thiophen-2-yl)acrylonitrile; 3-[4-(3-Formyl-1H-indol-1-yl)phenyl]-2-(2-thienyl)-2-propenenitrile; 2-Propenenitrile, 3-[4-(3-formyl-1H-indol-1-yl)phenyl]-2-(2-thienyl)-, (E)-; 1-(4-[(E)-2-Cyano-2-(thiophen-2-yl)vinyl]phenyl)-1H-indole-3-carbaldehyde; CAS 692287-44-8
EINECS	Contact for details

Quality Control

Our (E)-3-[4-(3-Formyl-1H-Indol-1-Yl)Phenyl]-2-(2-Thienyl)-2-Propenenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be sealed immediately after use to minimize exposure to air.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.