Description

3-Amino-4,5-Dihydronaphtho[1,2-B]Thiophene-2-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its fused naphthothiophene core. This compound is critical for the synthesis of complex organic molecules, particularly in medicinal chemistry and materials science research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Organic Synthesis Reagent: Serves as a versatile precursor for constructing complex polycyclic heteroaromatic systems via further functionalization of the amino and ester groups.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its unique fused-ring structure.
• Materials Science Precursor: Investigated for the synthesis of organic semiconductors, dyes, and pigments due to its electron-rich thiophene and naphthalene components.
• Academic & Industrial R&D: Essential for methodological studies in heterocyclic chemistry and for scaling up novel synthetic routes in process chemistry.

Basic Information

Product Name	3-Amino-4,5-Dihydronaphtho[1,2-B]Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	691393-99-4
Molecular Formula	C₁₅H₁₃NO₂S
Molecular Weight	271.33 g/mol
Synonyms	Methyl 3-amino-4,5-dihydrobenzo[1,2-b:4,3-b']dithiophene-2-carboxylate; 3-Amino-4,5-dihydro-naphtho[1,2-b]thiophene-2-carboxylic acid methyl ester; Methyl 3-amino-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylate; 2-Carbomethoxy-3-amino-4,5-dihydronaphtho[1,2-b]thiophene; 691393-99-4; 3-Amino-4,5-dihydro-naphtho[1,2-b]thiophene-2-carboxylic acid methyl ester; Naphtho[1,2-b]thiophene-2-carboxylic acid, 3-amino-4,5-dihydro-, methyl ester
EINECS	Contact for details

Quality Control

Our production of 3-Amino-4,5-Dihydronaphtho[1,2-B]Thiophene-2-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure consistency and compliance with research-grade and cGMP standards for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.