Description

4H-Cyclopenta[B]Thiophene-6-Carboxylicacid,5,6-Dihydro-5,5-Dimethyl-,(6R)-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) requiring specific chiral centers and fused heterocyclic systems. It is primarily sought by R&D and process development teams in the pharmaceutical and fine chemical industries for the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of proprietary drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders and metabolic diseases.
• Chiral Synthesis: Serves as a starting material or intermediate in asymmetric synthesis due to its defined (6R) stereochemistry, enabling the construction of enantiomerically pure compounds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space around the cyclopentathiophene scaffold.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Fine Chemical Production: A precursor for other high-value, specialized chemicals used in agrochemical or material science research.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	4H-Cyclopenta[B]Thiophene-6-Carboxylicacid,5,6-Dihydro-5,5-Dimethyl-,(6R)-(9Ci)
CAS No.	690656-65-6
Molecular Formula	C11H14O2S
Molecular Weight	210.29 g/mol
Synonyms	(6R)-5,6-Dihydro-5,5-dimethyl-4H-cyclopenta[b]thiophene-6-carboxylic acid; 4H-Cyclopenta[b]thiophene-6-carboxylic acid, 5,6-dihydro-5,5-dimethyl-, (6R)-; (6R)-5,5-Dimethyl-5,6-dihydro-4H-cyclopenta[b]thiophene-6-carboxylic acid; (R)-5,5-Dimethyl-5,6-dihydro-4H-cyclopenta[b]thiophene-6-carboxylic acid; 690656-65-6; UNII-7K4X9U5F8I; SCHEMBL218290; CHEMBL3185229
EINECS	Contact for details

Quality Control

Our 4H-Cyclopenta[B]Thiophene-6-Carboxylicacid,5,6-Dihydro-5,5-Dimethyl-,(6R)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with client specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under ICH guidelines and can supply material suitable for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled in accordance with good laboratory practices for such materials. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.